Carpal Tunnel Syndrome

How is Congenital Predisposition related to Carpal Tunnel Syndrome?


Carpal tunnel syndrome (CTS) is a musculoskeletal disorder affecting the hands and arms. The condition is caused by a pinched nerve in the wrist, which causes pain and loss of function in the hand, wrist, and arm. It is more common in people who do repetitive work, such as typists and computer users. Women and older people are at an increased risk of CTS, and some doctors believe it is hereditary in those with a family history.

Carpal tunnel syndrome surgery, or CTS, affects millions of people across the world. While an injury typically causes it, it is also possible to be caused by congenital predisposition. Here’s how.

  • A high family predisposition is probably correlated with several hereditary traits (Examples: stature, thicker transverse ligament, square wrist).
  • CTS is also linked to several genetic medical disorders (For example, genetic neuropathy with a propensity for pressure palsies, diabetes, thyroid disease.)
  • Collagen synthesis, collagen breakdown, and protection against the effects of oxidative stress in connective tissue are thought to be three distinct pathways implicated in the genetic susceptibility to CTS.

Apart from genetic disposition, Carpal Tunnel Syndrome can develop with other medical conditions. That constitutes:

  • a wrist injury that is sudden and severely deformed
  • lesions that take up space in the carpal tunnel (e.g., flexor tenosynovitis, ganglions, haemorrhage, aneurysms, anomalous muscles, various tumours, edema)
  • Diabetes
  • thyroid problems (usually myxedema)
  • inflammatory wrist arthritides such as rheumatoid arthritis
  • In the most recent menopause, including after oophorectomy 
  • kidney dialysis
  • Acromegaly
  • Amyloidosis

Not just genetics, CTS can develop from various other factors like demographics and vocational/avocational activities.

  • Demographic Factors include ageing, female gender, a higher BMI that too recently increased, squared-off wrist, Short height, Dominant hand, Race(white)
  • Vocational and Avocational activities include prolonged, violent force applied to the wrist, wrist position that is excessive and protracted, excessive repetition of exercises, and exposure to cold or vibration.


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YKOrthopaedics is your one-stop solution for bone-related injuries, Syndromes and related treatment. Contact us at +91 8851376606, and consult our doctor now. 

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